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1-Methyl-L-tryptophan

IDO inhibitor
 
ALX-106-040-M050 50 mg 34.00 USD
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Competitive inhibitor of indoleamine 2,3-dioxygenase (IDO).

Product Specification

Alternative Name:1-MT
 
Formula:C12H14N2O2
 
MW:218.3
 
CAS:21339-55-9
 
RTECS:YN7135000
 
Purity:≥95% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in acidic or basic aqueous solutions. Soluble in acetic acid 2% (m/v).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
106-040
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106-040

Product Literature References

The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells: C.A. Opitz, et al.; PLoS One 6, e19823 (2011), Abstract; Full Text
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway: H. J. Ball, et al.; Int. J. Biochem. Cell Biol. 41, 467 (2009), Abstract;
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses: D.Y. Hou, et al.; Cancer Res. 67, 792 (2007), Abstract;
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan: R. Metz, et al.; Cancer Res. 67, 7082 (2007), Abstract;
Prevention of allogeneic fetal rejection by tryptophan catabolism: D.H. Munn, et al.; Science 281, 1191 (1998), Abstract;
1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase: S.G. Cady & M. Sono; Science 291, 326 (1991), Abstract;

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