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O-Phospho-L-serine

NMDA receptor antagonist
 
ALX-106-024-G001 1 g 34.00 USD
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L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor. Inhibits proliferation. Enhances neuronal differentiation in progenitor cells.

Product Specification

Alternative Name:L-Phosphoserine, L-Serine-O-phosphate
 
Formula:C3H8NO6P
 
MW:185.1
 
CAS:407-41-0
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Store tightly sealed. Use fresh solutions.
 
106-024
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106-024

Product Literature References

Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998), Abstract;
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review),
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993), Abstract;
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991), Abstract;

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