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S-Trityl-L-cysteine

Cell cycle blocker
 
ALX-105-011-M500 500 mg 56.00 USD
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Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31µM).

Product Specification

Alternative Name:NSC 83265, STLC
 
Formula:C22H21NO2S
 
MW:363.5
 
CAS:2799-07-7
 
RTECS:AY7710000
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or acetic acid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
105-011
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105-011

Product Literature References

S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression: D.A. Skoufias, et al.; J. Biol. Chem. 281, 17559 (2006), Abstract; Full Text
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities: S. DeBonis, et al.; Mol. Cancer Ther. 3, 1079 (2004), Abstract; Full Text

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Kinesin
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Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
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