N-Acetyl-L-cysteine



ALX-105-005-G001	1 g	16.00 USD

ALX-105-005-G005	5 g	26.00 USD

Derivative of cysteine wherein an acetyl group is attached to the N. Is used as a specific antidote in cases of acetaminophen overdose.

Product Specification

Alternative Name:	LNAL, N-Acetyl-3-mercaptoalanine, L-α-Acetamido-β-mercaptopropionic acid, NAC

Formula:	C₅H₉NO₃S

MW:	163.2

Purity:	≥98% (TLC)

Appearance:	White to off-white crystalline solid.

CAS:	616-91-1

MI:	14: 88

RTECS:	HA1660000

Solubility:	Soluble in 5M hydrochloric acid (hot) (100mg/ml), methanol (50mg/ml), water or 100% ethanol; insoluble in chloroform or ether.

Long Term Storage:	+4°C

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Product Literature References

Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000), Abstract;

Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells: H. Kim, et al.; Free Radic. Biol. Med. 29, 674 (2000), Abstract;

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice: E. Ho, et al.; Faseb. J. 13, 1845 (1999), Abstract;

Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells: J.C. Tsai, et al.; J. Biol. Chem. 271, 3667 (1996), Abstract; Full Text

Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1: H. Schenk, et al.; PNAS 91, 1672 (1994), Abstract;

Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells: D. Salvemini, et al.; Br. J. Pharmacol. 108, 162 (1993), Abstract;

Modulation of platelet function by free radicals and free-radical scavengers: D. Salvemini & R. Botting; TIPS 14, 36 (1993), (Review), Abstract;