Progranulin (mouse) ELISA Kit



AG-45A-0019EK-KI01	96 wells		540.00 USD

AG-45A-0019TP-KI01	2x96 wells	Twin Plex	810.00 USD

AG-45A-0019PP-KI01	5x96 wells	Penta Plex	1'730.00 USD

Product Specification

Alternative Name:	Proepithelin, PEPI, PC Cell-derived Growth Factor

Sensitivity:	60pg/ml (range 0.125 to 8ng/ml)

Specificity:	Does not cross-react with human and rat progranulin.

Application:	For the quantitative determination of progranulin in mouse serum or cell culture supernatants.

Long Term Storage:	+4°C

Miscellaneous/General:	Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).

Manufacturer:	Manufactured by AdipoGen, Inc.

General Literature References

Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review), Abstract;

Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review), Abstract; Full Text

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003), Abstract;

Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003), Abstract;

Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990), Abstract;