Progranulin (human) ELISA Kit



AG-45A-0018EK-KI01	96 wells		520.00 USD

AG-45A-0018TP-KI01	2x96 wells	Twin Plex	780.00 USD

AG-45A-0018PP-KI01	5x96 wells	Penta Plex	1'660.00 USD

Product Specification

Alternative Name:	Proepithelin, PEPI, PC Cell-derived Growth Factor

Sensitivity:	32pg/ml (range 0.0625 to 4ng/ml)

Specificity:	Does not cross-react with mouse and rat progranulin.

Application:	For the quantitative determination of progranulin in human serum, plasma or cell culture supernatant.

Long Term Storage:	+4°C

Miscellaneous/General:	Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).

Manufacturer:	Manufactured by AdipoGen, Inc.

Product Literature References

Serum progranulin concentrations may be associated with macrophage Infiltration into omental adipose tissue: B.S. Youn, et al.; Diabetes 58, 627 (2009), Abstract;

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008), Abstract;

General Literature References

Progranulin: normal function and role in neurodegeneration: J. L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review), Abstract;

Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review), Abstract; Full Text

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003), Abstract;

Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003), Abstract;

Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990), Abstract;