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Glucosidase II α polyclonal antibody

 
ADI-VAP-PT034-C 25 µl 90.00 USD
 
ADI-VAP-PT034-E 100 µl 269.00 USD
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Product Specification

Alternative Name:GBA, GCB, GLUC
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human α-Glucosidase II.
 
UniProt ID:Q14697
 
Species reactivity:Human, Mouse
Bovine, Dog, Guinea pig, Hamster, Monkey, Rabbit, Sheep
 
Applications:IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:50)
Western Blot (1:500, colorimetric, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Whole rabbit serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Alpha-glucosidase II is a 110 kDa glycosylated ER resident protein that is involved in trimming of glucose from newly synthesized glycosylated proteins. Together with an 80 kDa beta subunit, these polypeptides remove two Alpha-1,3-linked glucose from high mannose oligosaccharides linked to asparagine residue on glycoprotein. Alpha-glucosidase II-mediated glucose trimming is necessary for the interaction of clanexin with monoglucosylated substrates such as influenza virus hemagglutinin (HA), MHC Class I, and T-cell antigen receptor (TCR).
 
VAP-PT034-Antibody-Blot
ADI-VAP-PT034 IHC
IHC Analysis: Human placenta tissue stained with Glucosidase II α, pAb at 1:100.
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VAP-PT034-Antibody-Blot ADI-VAP-PT034 IHC

Product Literature References

The protein-tyrosine phosphatase CD45 reaches the cell surface via golgi-dependent and -independent pathways: H.L. Ostergaard, et al. ; J. Biol. Chem. 277, 50333 (2002), Application(s): IP using mouse samples, Abstract;
Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction: H.L. Ostergaard, et al. ; J. Biol. Chem. 275, 32071 (2000), Application(s): WB using mouse samples, Abstract;

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