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SNAP-25 monoclonal antibody (SP12)

 
ADI-VAM-SV012-D 50 µg 170.00 USD
 
ADI-VAM-SV012-F 200 µg 399.00 USD
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Product Specification

Alternative Name:Synaptosomal-associated protein 25
 
Clone:SP12
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human Synaptophysin monoclonal antibodies.
 
UniProt ID:P60880
 
GenBank ID:L19761
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~25kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.1mM PMSF and 50% glycerol.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Synaptic vesicle fusion reactions are mediated by a variety of SNAP proteins, including alpha and beta SNAPs and SNAP-25. Together with synaptotagmin and NSF, alpha-SNAP modulates the interaction of SNAP25, VAMP, and syntaxin in an ATP-dependent manner to form a 20S complex associated with synaptic vesicle docking and fusion. beta-SNAP interacts with synaptotagmin and may be involved in calcium-regulated exocytosis.
 
VAM-SV012 WB
Western blot analysis of SNAP-25: Lane 1: MW marker, Lane 2: Mouse Liver, Lane 3: Mouse Brain, Lane 4: Rat Brain.
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VAM-SV012 WB

Product Literature References

Disrupted dynamics of F-actin and insulin granule fusion in INS-1832/13 Beta-cells exposed to glucotoxicity: Partial restoration by glucagon-like peptide 1: A. Quinault, et al.; Biochim. Biophys. Acta 1862, 1401 (2016), Application(s): Western blotting, Abstract;
Distinct molecular determinants govern syntaxin 1A-mediated inactivation and G-protein inhibition of N-type calcium channels: G.W. Zamponi, et al. ; J. Neurosci. 21, 2939 (2001), Application(s): WB using rat samples, Abstract;
Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex: P. Davies, et al. ; Brain Res. 609, 20 (1993), Application(s): IHC using human samples, Abstract;

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