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PSD-95 monoclonal antibody (6G6-1C9)

ADI-VAM-PS002-C 25 µg 273.00 USD
ADI-VAM-PS002-E 100 µg 298.00 USD
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Product Specification

Alternative Name:Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, SAP90
Immunogen:Recombinant rat PSD-95.
UniProt ID:Q62108
Species reactivity:Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Immunocytochemistry (12.5µg/ml)
Western Blot (1:250, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~100kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively.
Western blot analysis of bovine brain tissue extract, probed with PSD-95 mAb (6G6-1C9).
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Product Literature References

Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology: M. Kaneda, et al.; Sci. Rep. 8, 727 (2018), Abstract; Full Text
Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons: T. Imamura, et al. ; Eur. J. Neurosci. 16, 1313 (2002), Application(s): ICC using rat samples, Abstract;

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