KDEL receptor, mAb (KR-10)



ADI-VAA-PT048-D	50 µl	150.00 USD

ADI-VAA-PT048-F	200 µl	340.00 USD

Product Specification

Alternative Name:	Grp78, Grp94, Lysine-aspartic acid-glutamate-leucine, ERD, KDELR3

Purity Detail:	Ascites.

Formulation:	Liquid. Mouse ascites fluid containing 0.09% sodium azide.

Clone:	KR-10

Isotype:	Mouse IgG1

Immunogen:	Synthetic peptide corresponding to a portion of bovine KDEL Receptor.

Specificity:	Recognizes human, mouse and rat KDEL Receptor. Detects a band of ~23kDa by Western blot.

Application:	Immunohistochemistry Western Blot (1:250, colorimetric) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	The tetrapeptide KDEL, located at the carboxy-terminal sequences of luminal proteins, is a retrieval motif essential for the precise sorting of these proteins along the secretory pathway. KDEL proteins perform essential functions in the endoplasmic reticulum (ER) related to protein folding as well as assembly. The localization of chaperones and other soluble proteins to the ER is achieved by their continuous retrieval from post-ER compartments by the KDEL receptor (Erd2p), which is a membrane protein localized in the Golgi apparatus.

Background / Technical Information:	Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000105438).

Western blot analysis: Lane 1: MW marker, Lane 2: 20µg of HeLa cell lysate (heat shocked), Lane 3: 20µg of 3T3 cell lysate, Lane 4: 20µg of PC-12 cell lysate, Lane 5: 20µg of CHO-K1 cell lysate, Lane 6: 20µg of 3T3 cell lysate (heat shocked), Lane 7: 20µg of PC-12 cell lysate (heat shocked) probed with KDEL Receptor mAb at 1:250.

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Product Literature References

A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells: J.M. Villalba, et al. ; J. Bioenerg. Biomembr. 34, 209 (2002), Application(s): WB using human samples, Abstract;