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Synaptotagmin monoclonal antibody (ASV48)

 
ADI-SYA-148-D 50 µg 204.00 USD
 
ADI-SYA-148-F 200 µg 419.00 USD
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Product Specification

Alternative Name:SYT
 
Clone:ASV48
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Rat brain synaptic junction protein complexes.
 
UniProt ID:P21707
 
GenBank ID:X52772
 
Source:Purified from mouse ascites.
 
Species reactivity:Mouse, Rat
Monkey, Shark
 
Applications:ICC, IHC, IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:500)
Western Blot (0.1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~65kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Synaptotagmins (Syt) are membrane-trafficking proteins characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2-domains, C2A and C2B. At least twelve Synaptotagamins are expressed in vertebrates and can be found in both vesicular and plasma membranes.
 
Synaptotagmin monoclonal antibody (ASV48) Western blot
Western blot analysis of rat brain tissue extract, probed with Synaptotagmin, mAb (ASV48).
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Synaptotagmin monoclonal antibody (ASV48) Western blot

Product Literature References

Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells: A. Yamamoto, et al. ; J. Biol. Chem. 278, 3220 (2003), Application(s): ICC using rat samples, Abstract;
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells: K. Mikoshiba, et al. ; J. Biol. Chem. 277, 4601 (2002), Application(s): ICC using rat samples, Abstract;
Synaptotagmin IV is present at the Golgi and distal parts of neurites: K. Mikoshiba, et al. ; J. Neurochem. 74, 518 (2000), Application(s): WB using mouse samples, Abstract;
Synaptotagmin IV is present at the Golgi and distal parts of neurites: K. Mikoshiba, et al. ; J. Neurochem. 74, 518 (2000), Application(s): ICC, WB using rat samples, Abstract;
Comparison of immunolocalization patterns for the synaptic vesicle proteins p65 and synapsin I in macaque monkey retina: A.E. Hendrickson, et al. ; Synapse 14, 268 (1993), Application(s): ICC using monkey samples, Abstract;
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecterory tissue: W.D. Matthew, et al.; J. Cell Biol. 91, 257 (1981), Application(s): WB, IP using fish (shark) & rat samples, Abstract;

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