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UNC45a monoclonal antibody (AbS1)

 
ADI-SRA-1800-D 50 µg 184.00 USD
 
ADI-SRA-1800-F 200 µg 397.00 USD
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Product Specification

Clone:AbS1
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Recombinant human UNC45.
 
UniProt ID:Q9H3U1
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~98kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:GC UNC45 (general cell UNC45/unc45a) is an Hsp90 co-chaperone that has been shown to play a critical role in the chaperoning of myosin proteins as well as the progesterone receptor (PR). There are two known vertebrate isoforms of UNC45 that are functional orthologs of the C. elegans unc-45, an important protein in the development of organized body wall muscles. The vertebrate general cell form (GC UNC45/unc45a) is ubiquitously expressed, while the striated muscle-specific isoform (SM UNC45/unc45b) is found in cardiac and skeletal muscle. In vitro, GC UNC45 preferentially binds the Hsp90 beta isoform, and is specifically required for proper cellular distribution of Hsp90β but not Hsp90α.
 
SRA-1800 WB
Western blot analysis of UNC45: Lane 1: MW marker, Lane 2: HeLa, Lane 3: 3T3, Lane 4: PC-12.
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SRA-1800 WB

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