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FKBP59 monoclonal antibody (KN382/EC1)

 
ADI-SRA-1400-D 50 µg 194.00 USD
 
ADI-SRA-1400-F 200 µg 419.00 USD
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Product Specification

Alternative Name:HSP56, Heat shock protein 56, FK506 binding protein 1A
 
Clone:KN382/EC1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Partially purified 9S rabbit uterine progesterone receptor.
 
UniProt ID:P27124
 
GenBank ID:M84474
 
Species reactivity:Human, Mouse
Bovine, Guinea pig, Hamster, Mink, Monkey, Rabbit
 
Applications:IHC, IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (10µg/ml)
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~59kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:FKBP59, also known as Hsp56/p59 is an immunophilin that is a component of Hsp70/Hsp90/steroid receptor complexes. Expression of FKBP59 is increased in response to heat shock and ischemic stress, and is thought to play a role in the folding and cytoplasmic/nuclear distribution of steroid receptors.
 
Technical Info/Product Notes:Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000004478).
 
SRA-1400 WB
Western blot analysis of FKBP59 mAb (KN382/EC1) (Prod. No. ADI-SRA-1400): Lane 1: MW marker, Lane 2: HeLa Cell Lysate(heat shocked), Lane 3: MDBK Celll Lysate (heat shocked), Lane 4: VERO Cell Lysate (heat shocked), Lane 5: RK-13 Cell Lysate (heat shocked).
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SRA-1400 WB

Product Literature References

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain: S. Tsutsumi, et al. ; Nat. Struct. Mol. Biol. 16, 1141 (2009), Application(s): WB, IP using mouse cell lysates, Abstract;
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex: R. Voellmy, et al. ; J. Biol. Chem. 276, 45791 (2001), Application(s): WB using human samples, Abstract;
Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506: H.S. Gordon, et al. ; J. Pharmacol. Exp. Ther. 289, 1202 (1999), Application(s): Other using human samples, Abstract;

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