FKBP59, mAb (KN382/EC1)



ADI-SRA-1400-D	50 µg	165.00 USD

ADI-SRA-1400-F	200 µg	345.00 USD

Product Specification

Alternative Name:	Hsp56, FK506 binding protein 1A

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Clone:	KN382/EC1

Isotype:	Mouse IgG1

Immunogen:	Partially purified 9S rabbit uterine progesterone receptor.

Specificity:	Recognizes human, mouse, bovine, guinea pig, hamster, monkey, mink and rabbit FKBP59. Detects a band of ~59kDa by Western blot.

Application:	Immunohistochemistry Immunoprecipitation (10µg/ml) Western Blot (1:1000, colorimetric) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	FKBP59, also known as Hsp56/p59 is an immunophilin that is a component of Hsp70/Hsp90/steroid receptor complexes. Expression of FKBP59 is increased in response to heat shock and ischemic stress, and is thought to play a role in the folding and cytoplasmic/nuclear distribution of steroid receptors.

Background / Technical Information:	Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000004478).

Western blot analysis of FKBP59 mAb (KN382/EC1) (Prod. No. ADI-SRA-1400): Lane 1: MW marker, Lane 2: HeLa Cell Lysate(heat shocked), Lane 3: MDBK Celll Lysate (heat shocked), Lane 4: VERO Cell Lysate (heat shocked), Lane 5: RK-13 Cell Lysate (heat shocked).

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Product Literature References

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain: S. Tsutsumi, et al. ; Nat. Struct. Mol. Biol. 16, 1141 (2009), Application(s): WB, IP using mouse cell lysates, Abstract;

Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex: R. Voellmy, et al. ; J. Biol. Chem. 276, 45791 (2001), Application(s): WB using human samples, Abstract;

Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506: H.S. Gordon, et al. ; J. Pharmacol. Exp. Ther. 289, 1202 (1999), Application(s): Other using human samples, Abstract;