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HSP90α polyclonal antibody (PE conjugate)

 
ADI-SPS-771PE-050 50 µg 205.00 USD
 
ADI-SPS-771PE-200 200 µg 443.00 USD
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Product Specification

Alternative Name:HSP86, Heat shock protein 90α
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of mouse Hsp86.
 
UniProt ID:P07901
 
GenBank ID:X16857
 
Species reactivity:Human, Mouse, Rat
Beluga, Bovine, Dog, Fish, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
 
Applications:Flow Cytometry
 
Recommended Dilutions/Conditions:Flow Cytometry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Handling:Avoid vigorous centrifugation and vortexing. Do not freeze. Protect from light.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-α/β), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
 
SPS-771PE FC
Flow cytometry analysis of 106 Jurkat cells using Hsp90α, pAb (PE conjugate) at a concentration of 10 µg/ml.
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SPS-771PE FC

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Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
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