Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

HSP90α (human), (recombinant)

ADI-SPP-776-D 50 µg 216.00 USD
ADI-SPP-776-F 200 µg 495.00 USD
Do you need bulk/larger quantities?

Product Specification

Alternative Name:HSP86, Heat shock protein 90α
Recommended Dilutions/Conditions:Western Blot (50ng, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Source:Produced in E. coli.
UniProt ID:P07900
Formulation:Liquid. In Dulbecco's PBS containing 2.7mM potassium chloride, 1.5mM potassium phosphate, 137mM sodium chloride, 8.1mM sodium phosphate, and 10% glycerol.
Purity:≥90% (SDS-PAGE; Western blot)
Purity Detail:Purified by multi-step chromatography.
Application Notes:Western blot control.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Product Literature References

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors: T. Neubert, et al.; Bioorg. Med. Chem. Lett. 25, 1338 (2015), Application(s): Fluorescence Assay, Abstract;
A Repurposing Strategy for Hsp90 Inhibitors Demonstrates Their Potency against Filarial Nematodes: V. Gillan, et al.; PLoS Negl. Trop. Dis. 8, e2699 (2014), Application(s): Fluorescence polarization, Abstract; Full Text
Extracellular heat shock protein-90α: linking hypoxia to skincell motility and wound healing: W. Li, et al. ; EMBO J. 26, 1221 (2007), Abstract;
In vitro biological characterization of a novel, synthetic diarylpyrazole resorcinol class of heat shock protein90 inhibitors: P. Workman, et al. ; Cancer Res. 67, 2206 (2007), Abstract;

Related Products

Rabbit anti-rat IgG, polyclonal antibody (HRP conjugate) 

ELISA, IHC, WB | Print as PDF
ADI-SAB-200-J 1 ml 136.00 USD
Do you need bulk/larger quantities?

HeLa (heat shocked) , (cell lysate) 

Human, WB | Print as PDF
ADI-LYC-HL101-F 200 µg 111.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
HSP90 Recombinant protein
By catalog section:


Technical Service
Customer Service

Related Literature

Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,