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PERK (CT domain) (human), (recombinant) (His-tag)

 
ADI-SPP-768-0050 50 µg 189.00 USD
 
ADI-SPP-768-0200 200 µg 452.00 USD
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Product Specification

Alternative Name:EIF2AK3, Pek
 
MW:~69kDa
 
Source:Produced in E. coli. Recombinant human PERK (aa 536-1116).
 
UniProt ID:Q9NZJ5
 
Gene/Protein Identifier:NP_004827 (RefSeq)
 
Formulation:Liquid. In 50mM TRIS, pH 7.5, containing 100mM sodium chloride, 1mM dithiothreitol, and 20% glycerol.
 
Purity:≥95% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Applications:WB
 
Application Notes:Western blot control.
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-80°C
 
Long Term Storage:-80°C
 
Handling:After reconstitution, prepare aliquots and store at -80°C Avoid freeze/thaw cycles.
 
Scientific Background:The endoplasmic reticulum (ER)-resident protein kinase PERK (also known as Pek, or Eukaryotic initiation factor 2 α-subunit kinase 3 (EIF2AK3)) attenuates protein synthesis in response to ER stress through the phosphorylation of translation initiation factor eIF2α on serine 51. A Type I membrane protein located in the ER, PERK is a critical regulator of the unfolded protein response (UPR). Defects in PERK are the cause of Wolcott-Rallison syndrome (WRS).
 
ADI-SPP-768 His WB
Western Blot analysis of PERK protein (Prod. No. ADI-SPP-768) probed with anti-6x His tag antibody. Lane 1: MW marker, Lane2: 50 ng, Lane 3: 100 ng.
ADI-SPP-768 PERK WB
Western Blot analysis of PERK protein (Prod. No. ADI-SPP-768) probed with anti-PERK antibody. Lane 1: MW marker, Lane2: 50 ng, Lane 3: 100 ng.
ADI-SPP-768 SDS-PAGE
SDS-PAGE Analysis: Lane 1: MW marker; Lane 2: 1.0 μg of purified PERK protein (Prod. No. ADI-SPP-768).
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ADI-SPP-768 His WB ADI-SPP-768 PERK WB ADI-SPP-768 SDS-PAGE

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