United States
Grp78/BiP (hamster), (recombinant)
| ADI-SPP-765-D | 50 µg | 180.00 USD |  |
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| ADI-SPP-765-F | 200 µg | 430.00 USD | |
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Product Specification
| Alternative Name: | HspA5, Hsp70-5, Heat shock protein 70 family |
| Purity Detail: | Purified by multi-step chromatography. |
| MW: | ~78kDa |
| Purity: | ≥80% (SDS-PAGE; Western blot) |
| Formulation: | Liquid. In TRIS buffer, pH 7.5, containing sodium chloride, glycerol, and DTT. |
| Source/Host: | Produced in E. coli. |
| Application: | Western Blot (control, 100ng, colorimetric) Optimal conditions must be determined individually for each application. |
| Long Term Storage: | -80°C |
| Miscellaneous/General: | Grp78, a 78 kDa glucose-regulated protein also known as BiP or immunoglobulin heavy chain binding protein, is a stress-response protein induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding and assembly of many membrane bound and secreted proteins. Grp78 is critical for maintenance of cell homeostasis and the prevention of apoptosis. Grp78 protein levels provide a reliable biomarker of hypoglycemia as well as serve a neuroprotective function in neurons exposed to glutamate and oxidative stress. Reduced Grp78 levels occur in the brains of Alzheimer’s Disease patients, and decreased Grp78 expression appears to be associated with missense mutations in the human presenilin-1 (PS1) gene. The induction of the Grp78 protein is associated with the development of drug-resistance to anti-tumor drugs. |
SDS-PAGE analysis: Lane 1: MWM, Lane 2: 0.5µg, Lane 3: 1µg, Lane 4: 2µg, Lane 5: 5µg of Recombinant Grp78 Hamster Protein.
Western Blot analysis: Lane 1: MW marker, Lane 2 and 3: Recombinant Grp78 Hamster Protein probed with anti-Recombinant Grp78 (Bip) pAb.
Western Blot analysis: Lane 1: MWM, Lane 2 and 3: Recombinant Grp78 Hamster Protein probed with Anti-KDEL (Grp78, Grp94) mAb.
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Product Literature References
Differential protein expression during aging in ventricular myocardiumof Fischer 344 x Brown Norway hybrid rats: F. Witzmann, et al. ; Exp. Gerontol. 43, 909 (2008), Abstract;
Fingerprinting the circulating repertoire of antibodies from cancer patients: W. Arap, et al. ; Nat. Biotechnol. 21, 57 (2003), Application(s): WB , Abstract;
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78: D.E. Bredesen, et al. ; FEBS Lett. 514, 122 (2002), Application(s): WB , Abstract;
The dynamic role of GRP78/BiP in the coordination of mRNA translation with protein processing: C.O. Brostrom, et al. ; J. Biol. Chem. 274, 486 (1999), Application(s): WB , Abstract;
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