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HSP47 (human), (recombinant)

 
ADI-SPP-535-D 50 µg 184.00 USD
 
ADI-SPP-535-F 200 µg 444.00 USD
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Product Specification

Alternative Name:SerpinH1, Colligin, Gp46, Heat shock protein 47, Collagen binding protein
 
MW:~47kDa
 
Source:Produced in E. coli.
 
UniProt ID:P50454
 
Formulation:Liquid. In 30mM TRIS, pH 8.0, containing 100mM sodium chloride, 1mM DTT, and 0.4M arginine.
 
Purity:≥90% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Endotoxin Content:< 50 EU/mg determined by Limulus Amebocyte Lysate (LAL) gel clot assay.
 
Applications:WB
Antigen microarray
 
Application Notes:Western blot control.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Hsp47, also known as colligin and gp46, is an ER-resident collagen-specific stress glycoprotein involved in the synthesis and assembly of varoius collagens as a molecular chaperone. Hsp47 is a member of the serpin superfamily, but localizes to the ER via binding of its C-terminal RDEL sequence to KDEL receptors in the ER. Hsp47 binds procollagen co-translationally as it enters the ER, and dissociates prior to its secretion.
 
ADI-SPP-535 SDS-PAGE
SDS-PAGE Analysis. Lane 1: MW marker, Lane 2: 1.0 µg of purified Hsp47 (Prod. No. ADI-SPP-535)
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ADI-SPP-535 SDS-PAGE

Product Literature References

Antigen microarrays identify unique serum autoantibody signatures inclinical and pathologic subtypes of multiple sclerosis: H. Weiner, et al. ; PNAS 105, 18889 (2008), Application(s): Antigen Microarray , Abstract;

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