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HSF1 monoclonal antibody (10H8)

 
ADI-SPA-950-D 50 µg 184.00 USD
 
ADI-SPA-950-F 200 µg 367.00 USD
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Product Specification

Alternative Name:HSTF1, Heat shock factor protein 1
 
Clone:10H8
 
Host:Rat
 
Isotype:IgG1
 
Immunogen:Recombinant mouse HSF1.
 
UniProt ID:P38532
 
Gene/Protein Identifier:NM_008296 (RefSeq)
 
Species reactivity:Human, Mouse, Rat
Monkey, Rabbit
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Predicted MW of ~60kDa. Detects a band of ~85kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.
 
SPA-950 IHC
Immunohistochemistry analysis of human skeletal muscle tissue stained with HSF1, mAb (10H8) at 10µg/ml.
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SPA-950 IHC

Product Literature References

Oxymatrine inhibits microglia activation via HSP60-TLR4 signaling: F. Ding, et al.; Biomed. Rep. 5, 623 (2016), Application(s): Western Blot, BV2 cells, Abstract; Full Text
Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion: P.T. White, et al.; Surgery 159, 142 (2015), Application(s): Western blot, Abstract;
Basal and stress-induced Hsp70 are modulated by ataxin-3: C.P. Reina, et al.; Cell Stress Chaperones 17, 729 (2012), Application(s): WB using mouse cell lysate, Abstract; Full Text

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Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
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