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PDI monoclonal antibody (1D3) (PE conjugate)

 
ADI-SPA-891PE-D 50 µg 387.00 USD
 
ADI-SPA-891PE-F 200 µg 483.00 USD
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Product Specification

Alternative Name:P4HB, protein disulfide isomerase
 
Clone:1D3
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI.
 
UniProt ID:P04785
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
 
Applications:Flow Cytometry
 
Recommended Dilutions/Conditions:Flow Cytometry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~58kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles. Protect from light.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.
 
SPA-891PE FC
Flow cytometry analysis of 106 Jurkat cells stained using PDI mAb (1D3), R-Phycoerythrin Conjugate at a concentration of 10µg/ml.
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SPA-891PE FC

Product Literature References

Cell surface thiol isomerases may explain the platelet-selective action of S-nitrosoglutathione: F. Xiao, et al.; Nitric Oxide 25, 303 (2011), Application(s): FC analysis with human platelets, HCAEC and HCASMC, Abstract; Full Text

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