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HSP90 monoclonal antibody (AC88) (PE conjugate)

 
ADI-SPA-830PE-D 50 µg 211.00 USD
 
ADI-SPA-830PE-F 200 µg 443.00 USD
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Product Specification

Alternative Name:Heat shock protein 90
 
Clone:AC88
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Achlya ambisexualis (water mold) Hsp90.
 
UniProt ID:Q8LLI6
 
Species reactivity:Human, Mouse, Rat
Beluga, C. elegans, Chicken, Dog, E. coli, Fish, Guinea pig, Hamster, Mycobacterium leprae, Monkey, Mussel, Porcine, Rabbit, Scallop, Sheep, Water mold, Fusobacterium nucleatum
 
Applications:Flow Cytometry
 
Recommended Dilutions/Conditions:Flow Cytometry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles. Protect from light.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
 
ADI-SPA-830PE FC
Flow cytometry analysis of 106 Jurkat cells stained using HSP90 mAb (AC88), R-Phycoerythrin Conjugate at a concentration of 10µg/ml
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ADI-SPA-830PE FC

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Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
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