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United States 

HSP90 monoclonal antibody (AC88)

ADI-SPA-830-D 50 µg 188.00 USD
ADI-SPA-830-F 200 µg 407.00 USD
ADI-SPA-830-J 1 mg 1,651.00 USD
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Product Specification

Alternative Name:Heat shock protein 90
Immunogen:Achlya ambisexualis (water mold) Hsp90.
UniProt ID:Q8LLI6
Source:Purified from ascites
Species reactivity:Human, Mouse, Rat
Beluga, C. elegans, Chicken, Dog, E. coli, Fish, Guinea pig, Hamster, Mycobacterium leprae, Monkey, Mussel, Porcine, Rabbit, Scallop, Sheep, Water mold, Fusobacterium nucleatum
Applications:IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~90kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Immunohistochemistry analysis of human spleen tissue stained with HSP90, mAb (AC88) at 10µg/ml.
Western blot analysis of HSP90, mAb (AC88) (Prod. No. ADI-SPA-830): Lane 1: MW Marker; Lane 2: HSP90 (human), (native) (Prod. No. ADI-SPP-770); Lane 3: HSP90β, (human) (recombinant) (Prod. No. ADI-SPP-777); Lane 4: HSP90α (human), (recombinant) (Prod. No. ADI-SPP-776); Lane 5: HeLa (heat shocked) (Prod. No. ADI-LYC-HL101); Lane 6: 3T3 (heat shocked) (Prod. No. ADI-LYC-3T101; Lane 7: PC-12 (heat shocked) (Prod. No. ADI-LYC-PC101); Lane 8: CHO-K1 (heat shocked).
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Product Literature References

Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line: M. Gock, et al.; World J. Gastroenterol. 24, 3749 (2018), Abstract; Full Text
Osterix regulates corticalization for longitudinal bone growth via integrin β3 expression: Y.J. Moon, et al.; Exp. Mol. Med. 50, 80 (2018), Abstract; Full Text
Skeletal Muscle-Specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-Stimulated Glucose Uptake But Does Not Alter Whole Body Metabolism: J. Marshall, et al.; Diabetes Obes. Metab. 20, 1928 (2018), Abstract; Full Text
Targeting of drug-loaded nanoparticles to tumor sites increases cell death and release of danger signals: M. Alev, et al.; J. Control Release 285, 67 (2018), Abstract;
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin: B. Wang, et al.; Neurobiol. Dis. 109, 127 (2017), Application(s): Western Blot, Abstract;
Proinsulin and HSP90 as Biomarkers of Beta Cell Stress in the Early Period after Onset of Type 1 Diabetes: R.A. Watkins, et al.; Transl. Res. 168, 96 (2016), Application(s): Immunoblot Analysis, Abstract;
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice: D. Piedrahita, et al.; Front Cell Neurosci. 9, 498 (2016), Application(s): Western blot, Abstract; Full Text
Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells: S. Martin, et al.; Biochem. Pharmacol. 93, 290 (2015), Application(s): Flow cytometry using human melanoma cell lines A375, 451-LU, 451-LU/RES, M1617 and M1617/RES, Abstract;
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer : Y. Park, et al.; J. Breast Cancer 18, 249 (2015), Application(s): Immunohistochemical analysis, Abstract; Full Text
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis: J. Gong, et al.; Oncogene 34, 5640 (2015), Application(s): Western Blotting, Abstract;
Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration: J. Sailland, et al.; PNAS 111, 15108 (2014), Application(s): Western blot using human MDA-MB231 mammary epithelial cells and human PC3 prostate cancer cells, Abstract; Full Text
OLA1 protects cells in heat shock by stabilizing HSP70: R.F. Mao, et al.; Cell Death Dis. 4, e491 (2013), Application(s): Immunoprecipitation using human HEK-293T and MDA-MB-231 cells, Abstract; Full Text
Effects of neurotoxic insecticides on heat-shock proteins and cytokine transcription in Chinook salmon (Oncorhynchus tshawytscha): I. Werner, et al. ; Ecotoxicol. Environ. Saf. 72, 182 (2009), Application(s): WB using fish tissue, Abstract;
Bovine serum amine oxidase and spm potentiate docetaxel and interferon-α effects in inducing apoptosis on human cancer cells through the generation of oxidative stress: M. Caraglia, et al. ; Biochim. Biophys. Acta 1783, 2269 (2008), Application(s): WB using human cell lysates, Abstract;
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins: A. Lieberman, et al. ; Hum. Mol. Genet. 17, 3942 (2008), Application(s): WB using mouse cell lysates, Abstract;
Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases: S. Chen & I.R. Brown; Cell Stress Chaperones 12, 51 (2007), Application(s): WB, IF using rat tissue, Abstract;
Yeast is selectively hypersensitised to heat shock protein90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors: C. Prodromou, et al. ; Gene 302, 165 (2003), Application(s): WB using human & C. elegans samples, Abstract;
Intermittent hypoxia improves atrial tolerance to subsequent anoxia and reduces stress protein expression: D.J. Paterson, et al. ; Acta Physiol. Scand. 172, 89 (2001), Application(s): WB using guinea pig samples, Abstract;
Involvement of heat shock protein90 in the degradation of mutant insulin receptors by the proteasome: M. Kobayashi, et al. ; J. Biol. Chem. 273, 11183 (1998), Application(s): WB, ICC, IP using monkey samples, Abstract;
Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin: W.B. Pratt, et al. ; J. Biol. Chem. 272, 16224 (1997), Application(s): WB using mouse & human samples, Abstract;
Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species: D.O. Toft, et al. ; Biochemistry 24, 6586 (1985), Application(s): IP using chicken, mouse, rat, porcine & water mold samples, Abstract;

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