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HSP70/HSP72 monoclonal antibody (C92F3A-5) (DyLight™ 488 conjugate)

 
ADI-SPA-810-488-D 50 µg 209.00 USD
 
ADI-SPA-810-488-F 200 µg 450.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:Hsp70, HspA1A, Heat shock protein 70, HspA1B, Hsp72
 
Clone:C92F3A-5
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Native human Hsp70.
 
UniProt ID:P0DMV8 (HSPA1A), P0DMV9 (HSPA1B)
 
GenBank ID:M11717
 
Gene/Protein Identifier:NP_005336.3 (RefSeq), NM_005345 (RefSeq), 3303 (Entrez GeneID), 140550 (OMIM)
 
Species reactivity:Human, Mouse, Rat
Bovine, C. elegans, Chicken, Dog, Drosophila, Fish
 
Applications:Flow Cytometry
 
Recommended Dilutions/Conditions:Flow Cytometry (1:20)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~70kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles. Protect from light.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
 
SPA-810-488 FC
Flow cytometry analysis of 106 Jurkat cells stained using HSP70 (HSP72) mAb (C92F3A -5), DyLight™ 488 Conjugate at a concentration of 50µg/ml
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SPA-810-488 FC

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ADI-SAB-600-488-D 50 µg 194.00 USD
 
ADI-SAB-600-488-F 200 µg 410.00 USD
Do you need bulk/larger quantities?
 

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Heat Shock Proteins & the Cellular Stress Response Catalog
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