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Calcineurin A polyclonal antibody

 
ADI-SPA-610-D 50 µg 151.00 USD
 
ADI-SPA-610-F 200 µg 345.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to human calcineurin A.
 
UniProt ID:P16298
 
GenBank ID:M29550
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~61kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Calcineurin is a Ca2+/Calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit and a myristylated regulatory B subunit that binds calcium. Calcineurin, which is the target of immunosuppressant drugs such as cyclosporin A and FK506, controls the translocation of Nuclear factors of activated T-cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T-cells.
 
SPA-610 WB
Western blot analysis of ADI-SPA-610: Lane 1: Rat Brain Lysate, Lane 2: Mouse Brain Lysate.
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SPA-610 WB

Product Literature References

Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth: R.N. Michel, et al. ; J. Cell Biol. 151, 663 (2000), Application(s): WB using mouse samples, Abstract;

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Serine/threonine-protein phosphatase
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Serine/threonine-protein phosphatase Polyclonal antibody
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