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Metallothionein monoclonal antibody (UC1MT)

 
ADI-SPA-550-D 50 µg 204.00 USD
 
ADI-SPA-550-F 200 µg 418.00 USD
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Product Specification

Alternative Name:MT1A, Metallothionein MGC32848, MT1S, MTC, metallothionein 1A (functional)
 
Clone:UC1MT
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Cross-linked rabbit liver Metallothionein I and II.
 
Source:Purified from ascites.
 
Species reactivity:Human, Mouse, Rat
Fish, Horse, Rabbit
 
Applications:ELISA, IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~15kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Metallothioneins (MTs) are a class of ubiquitous, low molecular weight, cysteine-rich, metal binding proteins that function in the metabolism of zinc and copper. MT protects against exposure to toxic metals such as mercury and cadmium as well as a variety of other stress conditions. There are four mammalian MT isoforms: MT-I, -II, -III, -IV, each of which is encoded by individual genes. MT expression is induced by heavy metal cations, starvation, elevated temperature, lipopolysaccharide, inflammatory cytokines, free radicals, and ionizing radiation.
 
Metallothionein monoclonal antibody (UC1MT) Western blot
Western blot analysis of Prod. No. ADI-SPA-550: Lane 1: MW marker, Lane 2: MT I, Lane 3: MT II, Lane 4: Mummichug CdCl2.
Metallothionein monoclonal antibody (UC1MT) Immunohistochemistry
Immunohistochemistry analysis of human uterus tissue stained with Metallothionein, mAb (UC1MT) at 10µg/ml.
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Metallothionein monoclonal antibody (UC1MT) Western blot Metallothionein monoclonal antibody (UC1MT) Immunohistochemistry

Product Literature References

Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride.: R. Macirella & E. Brunelli; Int. J. Mol. Sci. 18, 824 (2017), Abstract; Full Text
Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio): R. Macirella, et al.; Int. J. Mol. Sci. 17, e361 (2016), Application(s): Immunohistochemistry, Abstract; Full Text
Metallothioneins and heat shock proteins 70 in Armadillidium vulgare (Isopoda, Oniscidea) exposed to cadmium and lead: V. Mazzei, et al.; Ecotoxicol. Environ. Saf. 116, 99 (2015), Application(s): Immunohistochemistry, Western Blotting , Abstract;
Identification and spatial analysis of metallothioneins expressed by the adult human lens: M. Kantorow, et al. ; Invest. Ophthalmol. Vis. Sci. 42, 188 (2001), Application(s): WB using human samples, Abstract;
Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated t: S.G. Kim, et al. ; Biochem. Pharmacol. 62, 1379 (2001), Application(s): WB using rat samples, Abstract;
Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production: E.A. Olson, et al. ; Toxicology 85, 161 (1993), Application(s): EIA (RB), WB using horse & rabbit samples, Abstract;
Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production: E.A. Olson, et al. ; Toxicology 85, 161 (1993), Application(s): WB using rabbit samples, Abstract;

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