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[pSer45]αB-Crystallin polyclonal antibody

ADI-SPA-226-D 50 µg 209.00 USD
ADI-SPA-226-F 200 µg 439.00 USD
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Product Specification

Alternative Name:CRYAB, HSPB5
Immunogen:Synthetic peptide corresponding to a portion of human αB-crystallin phosphorylated at Ser45.
UniProt ID:P02511
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Scallop, Xenopus
Applications:IP, WB
Recommended Dilutions/Conditions:Western Blot (1:500, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~22kDa by Western blot.
Purity Detail:Affinity purified.
Formulation:Liquid. In 0.1M sodium phosphate buffer, pH 7.0, containing 1.5% BSA and 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
SPA-226 WB
Western blot analysis of Crystallin alpha-B (pSer45): Lane 1: MW marker, Lane 2: alpha-B1 Crystallin Protein (phospho), Lane 3: alpha-B2 Crystallin Protein (non-phospho)
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SPA-226 WB

Product Literature References

Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis: S.W. Lee, et al.; PLoS One 11, e0166450 (2016), Abstract; Full Text

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