[pSer¹⁹]αB-Crystallin, pAb

Alternative Name:	CRYA, HspB, sHSP, HSPB5, small heat shock protein

Formulation:	Liquid. In sodium phosphate buffer, pH 7.0, containing 3% BSA.

Immunogen:	Synthetic peptide corresponding to a portion of human αB-crystallin. The sequence is completely conserved in mouse, rat and bovine phosphorylated at Ser¹⁹.

Source/Host:	From rabbit.

Specificity:	Recognizes human, mouse and bovine αB-crystallin.

Application:	Immunoprecipitation (12.5µg/ml) Western Blot (1µg/ml, colorimetric) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.