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αB-Crystallin polyclonal antibody

 
ADI-SPA-223-D 50 µg 169.00 USD
 
ADI-SPA-223-F 200 µg 374.00 USD
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Product Specification

Alternative Name:CRYAB, HSPB5
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human αB-Crystallin. The sequence is completely conserved in rat, rabbit, and bovine.
 
UniProt ID:P02511
 
GenBank ID:M28638
 
Species reactivity:Human, Mouse, Rat
Bovine, Porcine
 
Applications:IF, IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~20kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
 
αB-Crystallin polyclonal antibody Western blot
Western blot analysis of αB-Crystallin: Lane 1: MW marker, Lane 2:α-Crystallin (bovine), (native) (Prod No. ADI-SPP-225), Lane 3: αA-Crystallin (bovine), (native) (Prod No. ADI-SPP-226), Lane 4:αB-Crystallin (bovine), (native) (Prod No. ADI-SPP-227), Lane 5: β-Crystallin (bovine), (native) (Prod No. ADI-SPP-235)
αB-Crystallin polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human brain, cortex tissue stained with αB-Crystallin, pAb at 10µg/ml.
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αB-Crystallin polyclonal antibody Western blot αB-Crystallin polyclonal antibody Immunohistochemistry

Product Literature References

Histone deacetylase inhibitor SAHA treatment prevents the development of heart failure after myocardial infarction via an induction of heat-shock proteins in rats: S. Nagata, et al.; Biol. Pharm. Bull. (2019), Abstract;
Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization: X. Ma, et al.; J. Am. Heart Assoc. 8, e010866 (2019), Abstract;
A specific phosphorylation regulates the protective role of αA-crystallin in diabetes: A. Ruebsam, et al.; JCI Insight 3, e97919 (2018), Abstract;
Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration: P.G. Sreekumar, et al.; J. Control Release 283, 94 (2018), Abstract;
Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro: P. Murphy, et al.; Development 145, dev155838 (2018), Abstract; Full Text
Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients: M. Wattin, et al.; Int. J. Mol. Sci. 19, 178 (2018), Application(s): Western Blot, Abstract; Full Text
Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro: S.K. Shin, et al.; Exp. Mol. Med. 49, e287 (2017), Abstract; Full Text
HSPB7 is indispensable for heart development by modulating actin filament assembly: T. Wu, et al.; PNAS 114, 11956 (2017), Abstract; Full Text
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination: H.F. Kuipers, et al.; PNAS 114, E1745 (2017), Abstract; Full Text
Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats: B. Bartelt-Kirbach, et al.; Cell Stress Chaperones 22, 653 (2017), Abstract; Full Text
Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function: M.I. Ahmed, et al.; J. Thorac. Cardiovasc. Surg. 152, 1059 (2016), Abstract; Full Text
Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling: Q. Xie, et al.; J. Biol. Chem. 291, 3947 (2016), Abstract; Full Text
Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes: E. Tian, et al.; Cell Rep. 16, 781 (2016), Abstract;
Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities: A. A. Sosunov, et al.; Acta Neuropathol. Commun. 3, 17 (2015), Application(s): Immunohistochemistry, Abstract; Full Text
Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance: J. Leyk, et al.; J. Mol. Neurosci. 55, 1031 (2015), Abstract;
Selective and Compartmentalised Myelin Expression of HspB5: S. Quraishe, et al.; Neuroscience 316, 130 (2015), Application(s): Immunohistochemistry, Abstract;
The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells: S. Kuespert, et al.; J. Cell. Mol. Med. 19, 1010 (2015), Application(s): Western Blotting, Immunohistochemistry, Abstract; Full Text
alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress: D. Hinton, et al. ; Mol. Vis. 13, 566 (2007), Application(s): WB, IF using human tissue culture & cell lysates, Abstract;
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis: C.C. Glembotski, et al. ; Circ. Res. 92, 203 (2003), Application(s): WB using rat samples, Abstract;
Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells: D. Drenckhahn, et al. ; Histochem. Cell Biol. 117, 203 (2002), Application(s): WB using human & porcine samples, Abstract;
Effects of body temperature during exercise training on myocardial adaptations: J.W. Starnes, et al. ; Am. J. Physiol. Heart Circ. Physiol. 280, H2271 (2001), Application(s): WB using rat samples, Abstract;
Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis: H.D. Durham, et al. ; J. Biol. Chem. 276, 12791 (2001), Application(s): WB, IP using mouse samples, Abstract;

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