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αB-Crystallin polyclonal antibody

ADI-SPA-223-D 50 µg 169.00 USD
ADI-SPA-223-F 200 µg 374.00 USD
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Product Specification

Alternative Name:CRYAB, HSPB5
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human αB-Crystallin. The sequence is completely conserved in rat, rabbit, and bovine.
UniProt ID:P02511
GenBank ID:M28638
Species reactivity:Human, Mouse, Rat
Bovine, Porcine
Applications:IF, IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~20kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
Immunohistochemistry analysis of human brain, cortex tissue stained with αB-Crystallin, pAb at 10µg/ml.
Western blot analysis of αB-Crystallin: Lane 1: MW marker, Lane 2:α-Crystallin (bovine), (native) (Prod No. ADI-SPP-225), Lane 3: αA-Crystallin (bovine), (native) (Prod No. ADI-SPP-226), Lane 4:αB-Crystallin (bovine), (native) (Prod No. ADI-SPP-227), Lane 5: β-Crystallin (bovine), (native) (Prod No. ADI-SPP-235)
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Product Literature References

A specific phosphorylation regulates the protective role of αA-crystallin in diabetes: A. Ruebsam, et al.; JCI Insight 3, e97919 (2018), Abstract;
Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients: M. Wattin, et al.; Int. J. Mol. Sci. 19, 178 (2018), Application(s): Western Blot, Abstract; Full Text
Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities: A. A. Sosunov, et al.; Acta Neuropathol. Commun. 3, 17 (2015), Application(s): Immunohistochemistry, Abstract; Full Text
Selective and Compartmentalised Myelin Expression of HspB5: S. Quraishe, et al.; Neuroscience 316, 130 (2015), Application(s): Immunohistochemistry, Abstract;
The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells: S. Kuespert, et al.; J. Cell. Mol. Med. 19, 1010 (2015), Application(s): Western Blotting, Immunohistochemistry, Abstract; Full Text
alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress: D. Hinton, et al. ; Mol. Vis. 13, 566 (2007), Application(s): WB, IF using human tissue culture & cell lysates, Abstract;
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis: C.C. Glembotski, et al. ; Circ. Res. 92, 203 (2003), Application(s): WB using rat samples, Abstract;
Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells: D. Drenckhahn, et al. ; Histochem. Cell Biol. 117, 203 (2002), Application(s): WB using human & porcine samples, Abstract;
Effects of body temperature during exercise training on myocardial adaptations: J.W. Starnes, et al. ; Am. J. Physiol. Heart Circ. Physiol. 280, H2271 (2001), Application(s): WB using rat samples, Abstract;
Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis: H.D. Durham, et al. ; J. Biol. Chem. 276, 12791 (2001), Application(s): WB, IP using mouse samples, Abstract;

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