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αA-Crystallin polyclonal antibody

 
ADI-SPA-221-D 50 µg 173.00 USD
 
ADI-SPA-221-F 200 µg 356.00 USD
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Product Specification

Alternative Name:CRYAA, HSPB4
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human αA-Crystallin. The sequence is completely conserved in frog and chicken.
 
UniProt ID:P02489
 
GenBank ID:U05569
 
Species reactivity:Human, Mouse
Bovine
 
Applications:IF, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~20kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
 
SPA-221 WB
Western blot analysis of Crystallin, alpha-A pAb: Lane 1: Crystallin, alpha Native Bovine Protein, Lane 2: Crystallin, alpha A Native Bovine Protein, Lane 3: Crystallin, alpha B Native Bovine Protein (Negative Control), Lane 4: Crystallin, beta Native Bovine Protein (Negative Control).
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SPA-221 WB

Product Literature References

Elevated retina-specific expression of the small heat shock protein,αA-crystallin, is associated with photoreceptor protection in experimental uveitis: N. Rao, et al. ; Invest. Ophthalmol. Vis. Sci. 49, 1161 (2008), Application(s): IP, IF using mouse cell lysates & tissue, Abstract;
alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress: D. Hinton, et al. ; Mol. Vis. 13, 566 (2007), Application(s): WB, IF using human tissue culture & cell lysates, Abstract;
Small heat-shock proteins select &UDelta;F508-CFTR for endoplasmic reticulum-associated degradation: J. Brodsky, et al. ; Mol. Biol. Cell 18, 806 (2007), Application(s): IP, WB using human cell lysates, Abstract;

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Catalogs
Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
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