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HSP110 polyclonal antibody

 
ADI-SPA-1101-E 100 µg 215.00 USD
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Product Specification

Alternative Name:HSP105, HspH1, Heat shock protein 105, Heat shock protein 110
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of hamster HSP110. The sequence is completely conserved in human and mouse.
 
UniProt ID:Q60446
 
GenBank ID:Z47807
 
Species reactivity:Human, Mouse, Rat
Bovine, Hamster, Monkey, Sheep, Yeast
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~110kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Hsp 110 belongs to a family of large stress proteins known as the Hsp110/SSE family, the mostly overlooked relatives of the well studied Hsp70 family. Members of this group, while significantly larger and containing sequences not present in the Hsp70 family, share 30-33% amino acid identity with members of the Hsp70 family, mostly in the conserved ATP-binding domain. Presently, all identified members of the Hsp70-like sequences belong to either the Hsp70 family or the Hsp110/SSE family. Hsp110 appears to be a normal constituent of mammalian cells with highest expression in the brain, and its induction by heat shock strongly correlates with cellular thermotolerance. Hsp110 may contribute to RNA stability, and its capacity to bind peptide has made Hsp110 a promising immunoadjuvant in anti-tumor vaccine development.
 

Product Literature References

Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis: J. Gong, et al.; Oncogene 34, 5640 (2015), Application(s): Western Blotting, Abstract;
Basal and stress-induced Hsp70 are modulated by ataxin-3: C.P. Reina, et al.; Cell Stress Chaperones 17, 729 (2012), Application(s): WB using mouse cell lysate, Abstract; Full Text
Identification of a major subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein: J.R. Subjeck, et al. ; J. Biol. Chem. 270, 15725 (1995), Application(s): WB using human samples, Abstract;

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