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Cu/Zn SOD polyclonal antibody

 
ADI-SOD-100-D 50 µg 184.00 USD
 
ADI-SOD-100-F 200 µg 399.00 USD
 
ADI-SOD-100-J 1 mg 1,424.00 USD
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Product Specification

Alternative Name:Superoxide Dismutase (Cu-Zn), Superoxide dismutase 1, SOD1
 
Host:Rabbit
 
Immunogen:Native human Cu/Zn SOD.
 
UniProt ID:P00441
 
Species reactivity:Human, Mouse, Rat
Clam
 
Applications:IF, IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunofluorescence (1:50-1:200)
Immunohistochemistry (paraffin sections, 1:50)
Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~23kDa (human) or ~19kDa (mouse and rat) by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD).
 
SOD-100 IF
Immunofluorescent analysis (confocal) staining of HeLa cells using Cu/Zn SOD pAb (green); nuclei are stained in blue pseudocolor using DRAQ5.
SOD-100 IHC
Immunohistochemistry analysis of human heart tissue stained with Cu/Zn SOD, pAb at 10µg/ml.
ADI-SOD-100 WB
Western blot analysis of Cu/Zn SOD, pAb (Prod. No. ADI-SOD-100): Lane 1: Rat liver tissue lysate, Lane 2: Mouse liver tissue lysate, Lane 3: HeLa cell lysate (Prod. No. ADI-LYC-HL100).
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SOD-100 IF SOD-100 IHC ADI-SOD-100 WB

Product Literature References

Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats: M. Thorwald, et al.; Redox Biol. 14, 371 (2017), Abstract; Full Text
Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy: Y. Kobatake, et al.; J. Neurol. Sci. 372, 369 (2017), Application(s): Immunocytochemistry of canine SOD1-transfected cells, human embryonic kidney (HEK) 293A cells, Abstract;
A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression: M. Kawaguchi, et al.; BMC Cancer 16, 805 (2016), Application(s): Western blot, nuclear and cytoplasmic protein extracts, Abstract; Full Text
Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium: M.D. Delp, et al.; Sci. Rep. 6, 29901 (2016), Application(s): Immunoblot Analysis, Abstract; Full Text
Cerebrovascular endothelial dysfunction induced by mercury exposure at low concentrations: G.A. Wiggers, et al.; Neurotoxicology 53, 282 (2016), Application(s): Western blot, Abstract;
Exposure of Female Rats to an Environmentally-Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis: P.L. Lefevre, et al. ; Biol. Reprod. 94, 9 (2016), Application(s): Western Blot, Abstract; Full Text
Photo-protective effect of sargachromenol against UVB radiation-induced damage through modulating cellular antioxidant systems and apoptosis in human keratinocytes: P.M. Fernando, et al.; Environ. Toxicol. Pharmacol. 43, 112 (2016), Application(s): Western blot, Abstract;
The effect of R-(-)-deprenyl administration on antioxidant enzymes in rat testis: F. Horvathova, et al. ; Eur. J. Pharmacol. 788, 21 (2016), Application(s): Immunohistochemistry, Abstract;
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants: T. Fujisawa, et al. ; Neurobiol. Dis. 82, 478 (2015), Application(s): Immunoblotting, Abstract;
Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy: S. Nakamae, et al.; Neurosci. 303, 229 (2015), Application(s): Western Blot, Abstract;
Changes of the Cytoplasmic Proteome in Response to Alcoholic Hepatotoxicity in Rats: D.H. Kim, et al. ; Int. J. Mol. Sci. 16, 18664 (2015), Application(s): Immunoblotting , Abstract; Full Text
Correlations between Cu, Zn- Superoxide dismutase and Macrophages or MUC5AC in Human Eosinophilic Chronic Rhinosinusitis: T. Kusunoki, et al.; J. Otol. Rhinol. S1, 1 (2015), Application(s): Immunostaining, Full Text
Effects of Exercise and Alpha-Lipoic Acid Supplementation on Brain Tissue Protection in Experimental Diabetes: Z. Pündük; (2015), (PhD thesis), Application(s): Western assay, Full Text
Respiratory syncytial virus infection downregulates antioxidant enzyme expression by TRIGGERING deacetylation-proteasomal degradation of NRF2: N. Komaravelli, et al.; Free Radic. Biol. Med. 88, 391 (2015), Application(s): Western Blot, Abstract;
Resveratrol and N-acetylcysteine influence redox balance in equine articular chondrocytes under acidic and very low oxygen conditions: J.A. Collins, et al.; Free Radic. Biol. Med. 86, 57 (2015), Application(s): Western Blot, Abstract;
The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues: K.M. Pate, et al.; J. Appl. Physiol. (1985) 118, 760 (2015), Application(s): Western Blotting, Abstract; Full Text
Versican Localizes to the Nucleus in Proliferating Mesenchymal Cells: J.M. Carthy, et al.; Cardiovasc. Pathol. 24, 368 (2015), Application(s): Western Blot, Abstract;
Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis: K. Watanabe, et al.; Int. J. Mol. Sci. 14, 10998 (2013), Application(s): Western blot, Abstract; Full Text
Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell: Y.N. Park, et al.; PLoS One 7, e40329 (2012), Application(s): WB using N2A and HeLA cells, Abstract; Full Text
A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice: D. Jaarsma, et al. ; Hum. Mol. Genet. 17, 2849 (2008), Application(s): WB using mouse tissue, Abstract;
Effect of exposure to benzo[a]pyrene on SODs, CYP1A1/1A2- and CYP2E1 immunopositive proteins in the blood clam Scapharca inaequivalvis: M. Monari, et al. ; Mar. Environ. Res. 63, 200 (2007), Application(s): WB using clam tissue, Abstract;
Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries: M.H. Laughlin, et al. ; J. Appl. Physiol. 93, 1685 (2002), Application(s): WB using rat samples, Abstract;
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity: G. Sobue, et al. ; J. Biol. Chem. 277, 36793 (2002), Application(s): IHC using human samples, Abstract;
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line: P. Brundin, et al. ; J. Biol. Chem. 277, 38884 (2002), Application(s): WB using human samples, Abstract;
Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis: H.D. Durham, et al. ; J. Biol. Chem. 276, 12791 (2001), Application(s): IP using human samples, Abstract;

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