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PKA Catalytic β (human), (recombinant) (GST-tag)

 
ADI-PPK-448-Z 5 µg 367.00 USD
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Product Specification

Alternative Name:cAMP-dependent protein kinase catalytic subunit β, Protein kinase A C-β
 
MW:~65kDa
 
Source:Produced in Sf9 insect cells using an N-terminal GST-tag. Produced in a baculovirus expression system.
 
UniProt ID:P22694
 
Formulation:Liquid. In 50mM Tris-HCl, pH 7.5, containing 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, and 25% glycerol.
 
Purity:≥80% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Applications:Kinase assay
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:PKA belongs to the cAMP-dependent protein kinase (PKA) family. PKA isoforms type I and II include respective dimeric R subunits RI and RII which each produce two subunits designated RI-α, RI-β, RII-α, and RII-β. The catalytic subunit also consists of more than one gene product. Researchers cloned mammalian catalytic subunit C-α, C-β, and C-γ cDNAs. The catalytic subunit C-β belongs to the Ser/Thr protein kinase family. Activated by cAMP, PKA C-β resides in the cytoplasm (inactive holoenzyme and monomeric catalytic subunit), and translocates into the nucleus (monomeric catalytic subunit). A number of inactive tetrameric holoenzymes result from the combination of homo- or heterodimers of the different regulatory subunits associated with the two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. PKA C-β acts as a p75 neurotrophin receptor (NTR)-interacting protein, which phosphorylates p75 (NTR) at Ser304.
 
PPK-448 SDS-PAGE
SDS-PAGE analysis of PKA Catalytic β (human), (recombinant).
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PPK-448 SDS-PAGE

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