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HIF-2 α polyclonal antibody

 
ADI-OSA-605-F 200 µg 323.00 USD
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Product Specification

Alternative Name:Hypoxia-inducible factor 2α
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human Hif-2α.
 
UniProt ID:Q99814
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:500-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~90kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex which regulates systemic, local and intracellular homeostatic responses elicited by hypoxia. HIF-1 is a heterodimer of HIF-1alpha and HIF-1beta. HIF-1beta is constitutively expressed and serves as a dimerization partner for several other transcription factors, while HIF-1alpha and the closely related HIF-2 are unique to HIF-1 and their expression is tightly regulated by cellular oxygen concentration. HIF-1 regulates a diverse group of genes, including erythropoietin, VEGF, glucose transporters, heme oxygenase, and NOS.
 
OSA-605 WB
Western blot analysis of lysates from (A) cobalt chloride treated HeLa cells and (B) untreated HeLa cells, probed with HIF-2α pAb.
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OSA-605 WB

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