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Drebrin monoclonal antibody (M2F6)

 
ADI-NBA-110-E 100 µg 329.00 USD
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Product Specification

Alternative Name:DBN
 
Clone:M2F6
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Chicken Drebrin E.
 
UniProt ID:P18302
 
Species reactivity:Human, Mouse, Rat
Bovine, Cat, Chicken, Rabbit
 
Applications:ICC, IHC, IP, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~110kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Drebrins are actin-binding proteins that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single Drebrin gene in the chicken brain. It has been suggested that Drebrin is one of the intracellular regulators of the neuronal morphogenesis.
 
Drebrin monoclonal antibody (M2F6) Western blot
Western blot analysis of Drebrin expression in mouse brain (1) NIH/3T3 (2), Jurkat (3), HeLa (4), and PC12 (5) using Drebrin mAb (M2F6).
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Drebrin monoclonal antibody (M2F6) Western blot

Product Literature References

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans: P. Kreis, et al.; Nat. Commun. 10, 486 (2019), Abstract; Full Text
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability: S. Kaniyappan, et al.; Alzheimers Dement. 13, 1270 (2017), Abstract;
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One 10, e0125119 (2015), Application(s): Immunostaining, Abstract; Full Text
Changes of drebrin expression in the visual cortex of the cat during development: K. Obata, et al. ; Neurosci. Res. 13, 33 (1992), Application(s): WB, IHC using feline samples, Abstract;
Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution: K. Obata, et al. ; Brain Res. 394, 233 (1986), Application(s): IHC, WB using chicken samples, Abstract;

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