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Drebrin monoclonal antibody (M2F6)

 
ADI-NBA-110-E 100 µg 313.00 USD
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Product Specification

Alternative Name:DBN
 
Clone:M2F6
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Chicken Drebrin E.
 
UniProt ID:P18302
 
Species reactivity:Human, Mouse, Rat
Bovine, Cat, Chicken, Rabbit
 
Applications:ICC, IHC, IP, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~110kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Drebrins are actin-binding proteins that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single Drebrin gene in the chicken brain. It has been suggested that Drebrin is one of the intracellular regulators of the neuronal morphogenesis.
 
NBA-110 WB
Western blot analysis of Drebrin expression in mouse brain (1) NIH/3T3 (2), Jurkat (3), HeLa (4), and PC12 (5) using Drebrin mAb (M2F6).
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NBA-110 WB

Product Literature References

Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One 10, e0125119 (2015), Application(s): Immunostaining, Abstract; Full Text
Changes of drebrin expression in the visual cortex of the cat during development: K. Obata, et al. ; Neurosci. Res. 13, 33 (1992), Application(s): WB, IHC using feline samples, Abstract;
Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution: K. Obata, et al. ; Brain Res. 394, 233 (1986), Application(s): IHC, WB using chicken samples, Abstract;

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