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Amyloid β monoclonal antibody (2C8)

 
ADI-NBA-104-E 100 µg 301.00 USD
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Product Specification

Clone:2C8
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Synthetic peptide corresponding to aa 1-16 of human Amyloid β.
 
UniProt ID:P05067
 
Species reactivity:Human
 
Crossreactivity:Weakly cross-reacts with mouse β-amyloid.
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (0.5-1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Predicted MW of ~4kDa.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Beta-amyloid/A-beta is the major protein component of neurofibrillary tangles and senile plaques, major neruopthological hallmarks of Alzheimer's disease (AD). Abeta occurs in two predominant forms with different COOH-termini, A-beta 40 and A-beta 42. A-beta is generated by proteolytic cleavage of the amyloid precursor protein (APP) at two sites by distinct secretases, the beta-site secretase BACE, and the multi-subunit gamma-secretase composed of presenilin, nicastrin, Aph-1, and Pen-2.
 

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