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GAD65/67 monoclonal antibody (9A6)

 
ADI-MSA-225-E 100 µg 313.00 USD
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Product Specification

Clone:9A6
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human GAD65.
 
UniProt ID:Q05329
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1-10µg/ml)
Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~65kDa and ~67kDa, (corresponding to GAD65 and GAD67, respectively) by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:GAD, glutamic acid decarboxylase, is an integral membrane protein that catalyzes the formation of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter. The biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system and modulation of cell proliferation, protein synthesis, and metabolism.
 
MSA-225 WB
Western blot analysis of mouse (1) and rat (2) brain extracts, probed with GAD65/67, mAb (9A6).
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MSA-225 WB

Product Literature References

Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated: D.H. Kim, et al.; Front. Neural Circuits 5, 5 (2011), Abstract;
Attractin/mahogany protein expression in the rodent central nervous system: K. Nakadate, et al.; J. Comp. Neurol. 508, 94 (2008), Abstract;
An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease: D.A. Pearce, et al. ; Hum. Mol. Genet. 11, 1421 (2002), Application(s): IHC, WB using human & mouse samples, Abstract;

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