GAD65/67, mAb (9A6)



ADI-MSA-225-E	100 µg	285.00 USD

Product Specification

Purity Detail:	Protein A affinity purified.

Formulation:	Liquid. In PBS containing 50% glycerol.

Clone:	9A6

Isotype:	Mouse IgG1

Immunogen:	Recombinant human GAD65.

Specificity:	Recognizes human, mouse, and rat GAD65/67. Detects bands of ~65kDa and ~67kDa, (corresponding to GAD65 and GAD67, respectively) by Western blot.

Application:	Immunohistochemistry (1-10µg/ml) Western Blot (1µg/ml, ECL) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	GAD, glutamic acid decarboxylase, is an integral membrane protein that catalyzes the formation of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter. The biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system and modulation of cell proliferation, protein synthesis, and metabolism.

Western blot analysis of mouse (1) and rat (2) brain extracts, probed with GAD65/67, mAb (9A6).

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Product Literature References

An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease: D.A. Pearce, et al. ; Hum. Mol. Genet. 11, 1421 (2002), Application(s): IHC, WB using human & mouse samples, Abstract;