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MEKK3 polyclonal antibody

 
ADI-KAS-MA013-C 25 µl 90.00 USD
 
ADI-KAS-MA013-E 100 µl 248.00 USD
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Product Specification

Alternative Name:MAP3K3, MEK kinase 3
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse MEKK3.
 
UniProt ID:Q61084
 
GenBank ID:U43187
 
Species reactivity:Human, Mouse, Rat
Dog, Drosophila, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:5,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Whole rabbit serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5.
 
ADI-KAS-MA013 IHC
IHC Analysis: Human uterus tissue stained with MEKK3, pAb at 1:100.
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ADI-KAS-MA013 IHC

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