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p38 MAPK polyclonal antibody

 
ADI-KAS-MA009-E 100 µl 282.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human p38. The sequence is completely conserved in mouse.
 
UniProt ID:Q16539.3
 
Gene/Protein Identifier:1432 (Gene ID)
 
Source:Whole rabbit serum.
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep
 
Applications:IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:500)
Western Blot (1:10,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~43kDa by Western blot.
 
Formulation:Liquid. Whole rabbit serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.
 
p38 MAPK polyclonal antibody Western blot
Western Blot analysis of p38 MAPK: Lane 1: MW Marker, Lane 2: HeLa, (Cell Lysate) (Prod. No. ADI-LYC-HL100), Lane 3: Brain (mouse), (tissue extract) (Prod. No. ADI-LYT-MB100), Lane 4: Brain (rat), (tissue extract) (Prod. No. ADI-LYT-RB100).
p38 MAPK polyclonal antibody Immunohistochemistry
IHC Analysis: Human spleen tissue stained with p38 MAPK, pAb at 10µg/ml.
p38 MAPK polyclonal antibody Immunohistochemistry
IHC Analysis: Human placenta tissue stained with p38 MAPK, pAb at 10µg/ml.
p38 MAPK polyclonal antibody Immunohistochemistry
IHC Analysis: Human tonsil tissue stained with p38 MAPK, pAb at 10µg/ml.
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p38 MAPK polyclonal antibody Western blot p38 MAPK polyclonal antibody Immunohistochemistry p38 MAPK polyclonal antibody Immunohistochemistry p38 MAPK polyclonal antibody Immunohistochemistry

Product Literature References

Proteasome Activation by Small Molecules: Y. Leestemaker, et al.; Cell Chem. Biol. 24, 725 (2017), Abstract;

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