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Cdc42/Rac polyclonal antibody

 
ADI-KAS-GP007-C 25 µl 96.00 USD
 
ADI-KAS-GP007-E 100 µl 237.00 USD
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Product Specification

Alternative Name:Cell division cycle 42
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human cdc42.
 
UniProt ID:P60953
 
Species reactivity:Human, Mouse, Rat
Bovine
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000 colorimetric, 1:1,000 ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Whole rabbit serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The cell division cycle (cdc) group of proteins consists of many protein classes, including cyclin dependent kinases (Cdks), phosphoprotein phosphatases, mitogen activated kinases, small GTPases, and cyclins. These proteins play a central role in regulating progression through the cell cycle through the formation and/or modification of key substrates. Cdc42 belongs to the Rho-family of GTPases, and promotes actin polymerization to form filopodia. Cdc25A is a dual-specificity phosphatase that acts on phosphorylated threonine and tyrosine residues of Cdks, leading to binding and activation of their partner cyclins.
 

Product Literature References

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases: T.I. Oprea, et al.; PLoS One 10, e014182 (2015), Abstract;

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