Product Specification
Alternative Name: | IκB kinase |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human IKKβ. The sequence differs from mouse IKKβ by one amino acid. |
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UniProt ID: | O14920 |
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GenBank ID: | AF029684.1 |
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Species reactivity: | Human
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Western Blot (2µg/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~87kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | Nuclear factor κ B (NF-κB) is a ubiquitous and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-κB activity. IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma. A molecule in the IKK complex was identified and designated IKKepsilon/IKK-iota. |
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Western blot analysis of IKK beta in Jurkat whole cell lysate with IKK beta antibody (C3) at 1:500 dilution.
Immunocytochemistry analysis of HeLa cells using IKK beta antibody at 10µg/ml.
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For Research Use Only. Not for use in diagnostic procedures.