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c-Jun polyclonal antibody

 
ADI-KAP-TF104-C 25 µg 110.00 USD
 
ADI-KAP-TF104-E 100 µg 281.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human c-Jun.
 
UniProt ID:P05412
 
Gene/Protein Identifier:NM_002228 (RefSeq)
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Drosophila, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
 
Applications:IF, IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:5)
Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~46kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:c-Jun, a component of the AP1 transcriptional apparatus, forms homo/heterodimers with Jun, Fos, ATF, or other trancriptional factors through its leucine zipper domain. The activity of c-Jun is enhanced upon by phosphorylation of serine 63 and serine 73 residues by Jnk (c-Jun N-Terminal Kinase). Signals relayed by Jnk through c-Jun regulate a range of cellular processes including cell proliferation, tumorigenesis, apoptosis, and embryonic development. Studies have shown that c-Jun plays an important role in neuronal apoptosis, regeneration, and protection.
 
KAP-TF104 IF
Immunofluorescent analysis (confocal) of HeLa cells using c-Jun pAb (green); nuclei are stained in blue pseudocolor using DRAQ5.
KAP-TF104 IHC
Immunohistochemistry analysis of human breast cancer tissue with c-Jun pAb.
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KAP-TF104 IF KAP-TF104 IHC

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