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PKG polyclonal antibody

 
ADI-KAP-PK005-D 50 µg 151.00 USD
 
ADI-KAP-PK005-F 200 µg 345.00 USD
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Product Specification

Alternative Name:Protein kinase G
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human PKG.
 
UniProt ID:Q13976
 
GenBank ID:D45864
 
Species reactivity:Human, Mouse, Rat
Porcine
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~75kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.
 
KAP-PK005 WB
Western blot analysis: Lane 1: MW marker, Lane 2: Mouse Brain Tissue Extract, Lane 3: Rat Brain Tissue Extract, Lane 4: EKS4 Cell Lysate; Lane 5: HS67 Cell Lysate probed with PKG pAb.
KAP-PK005 IHC
Immunohistochemistry analysis of human prostate tissue stained with PKG, pAb at 10µg/ml.
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KAP-PK005 WB KAP-PK005 IHC

Product Literature References

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress: J.J. Kim, et al.; PLoS Pathog. 11, e1004639 (2015), Application(s): Western Blotting, Abstract; Full Text
The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus: C. Mátyás, et al.; Cardiovasc. Diabetol. 14, 145 (2015), Application(s): Immunoblot analysis, Abstract; Full Text
cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I: R.B. Pilz, et al. ; J. Biol. Chem. 277, 32003 (2002), Application(s): IP (M), ICC (H) using mouse samples, Abstract;
Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation: S.A. Fisher, et al. ; J. Biol. Chem. 276, 37250 (2001), Application(s): IP, WB using rat samples, Abstract;

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