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PKG polyclonal antibody

 
ADI-KAP-PK002-D 50 µg 194.00 USD
 
ADI-KAP-PK002-F 200 µg 385.00 USD
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Product Specification

Alternative Name:Protein kinase G
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human PKG1β, with the subsitiution of a tryptophan residue for tyrosine at residue 9.
 
UniProt ID:Q13976
 
GenBank ID:Y07512
 
Source:Purified from rabbit serum.
 
Species reactivity:Human, Mouse, Rat
Bovine
 
Applications:ICC, IHC, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~80kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.
 
PKG polyclonal antibody Western blot
Western blot analysis of Prod. No. ADI-KAP-PK002: Lane 1: MW marker, Lane 2: HeLa cell lysate, Lane 3: Rat brain tissue extract, Lane 4: MDBK cell lysate.
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PKG polyclonal antibody Western blot

Product Literature References

The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis: S. Kato, et al.; Am. J. Physiol. Cell Physiol. 308, C944 (2015), Abstract; Full Text
Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle: J.M. Simard, et al. ; Circ. Res. 93, 805 (2003), Application(s): IHC, WB using rat samples, Abstract;
Protein kinase G activation of K(ATP) channels in human-cultured prostatic stromal cells: J.M. Haynes, et al. ; Cell. Signal. 14, 1023 (2002), Application(s): ICC using human samples, Abstract;
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin: R. Pamukcu, et al. ; Cancer Res. 60, 3338 (2000), Application(s): WB using human samples, Abstract;

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