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eIF4E-BP2 polyclonal antibody

 
ADI-KAP-MA112-E 100 µg 237.00 USD
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Product Specification

Alternative Name:Eukaryotic translation initiation factor 4E-binding protein 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human eIF4E-BP2. The sequence is completely conserved in mouse.
 
UniProt ID:Q13542
 
GenBank ID:L36056
 
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Porcine, Rabbit
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (4µg/ml colorimetric, 4µg/ml ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In borate buffered saline, pH 8.4, containing 25mM sodium borate, 100mM boric acid, 75mM sodium chloride, and 5mM EDTA.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The eukaryotic translation initiation factors (eIFs) regulate translation at the level of messenger RNA engagement by the ribosome. eIF-2alpha promotes the binding of the initiator tRNA to 40S ribosomal subunits, and is a key signaling component of the unfolded protein response (UPR). eIF-4E recruits mRNAs to the eIF4F complex through binding of their 5 N7-methylguanosine cap. eIF-4E binding proteins-1 and -2 are translational repressors, sequestering eIF-4E in conditions of low cellular demand for translation. Their dissociation from eIF-4E is regulated by phosphorylation in response to growth-promoting stimuli.
 
KAP-MA112-Antibody-Blot
ADI-KAP-MA112 IHC
IHC Analysis: Human pancreas tissue stained with eIF4E-BP2, pAb at 10µg/ml.
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KAP-MA112-Antibody-Blot ADI-KAP-MA112 IHC

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