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MAPKAPK-2 polyclonal antibody

 
ADI-KAP-MA015-D 50 µg Inquire for pricing
 
ADI-KAP-MA015-F 200 µg 367.00 USD
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Product Specification

Alternative Name:MAP kinase-activated protein kinase 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human MAPKAPK-2. The sequence is completely conserved in mouse, hamster and rabbit.
 
UniProt ID:P49137
 
Gene/Protein Identifier:NP_004750 (RefSeq), NP_116584 (RefSeq)
 
Species reactivity:Human, Mouse, Rat
Bovine, Dog
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:500 colorimetric, 1:500 ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~45-50kDa and ~65kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:MAP kinase-activated protein kinase-2 (MAPKAPK-2), also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase that contains a proline rich sequence and two putative SH3-binding sites. MAPKAPK-2 is activated in response to stress, IL-1 and TNF, possibly catalyzed by p38/Hog-dependent phosphorylation. One of the major substrates of MAPKAPK-2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from disruption of cytoskeleton during cellular stresses. Two isoforms are produced due to alternative splicing of the same gene which differ in their C-terminals. This antibody recognizes both isoforms.
 
KAP-MA015 WB
Western blot analysis of MAPKAPK-2: Lane 1: MW marker, Lane 2: MAPKAPK-2 Protein.
Please mouse over
KAP-MA015 WB

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