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MEK5 polyclonal antibody

 
ADI-KAP-MA003-E 100 µg 281.00 USD
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Product Specification

Alternative Name:MKK5, MAP kinase kinase 5
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human MEK5. The sequence is completely conserved in rat.
 
UniProt ID:Q13163
 
GenBank ID:U71088
 
Species reactivity:Human, Mouse, Rat
Dog, Monkey, Rabbit, Sheep, Xenopus
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~42kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.
 
ADI-KAP-MA003 WB
Western Blot analysis of MEK5, pAb (Prod. No. ADI-KAP-MA003): Lane 1: Jurkat, Lane 2: Mouse Testes, Lane 3: Rat Brain
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ADI-KAP-MA003 WB

Product Literature References

MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion: H.Y. Leung, et al. ; Oncogene 22, 1381 (2003), Application(s): IHC using human samples, Abstract;
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway: J.D. Lee, et al. ; J. Biol. Chem. 274, 36035 (1999), Application(s): WB using mouse samples, Abstract;

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