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eIF2 α polyclonal antibody

ADI-KAP-CP130-D 50 µg 226.00 USD
ADI-KAP-CP130-F 200 µg 441.00 USD
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Product Specification

Alternative Name:Eukaryotic translation initiation factor 2 subunit α
Immunogen:Synthetic peptide corresponding to a portion of rat eIF2-α.
UniProt ID:P68101
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep
Applications:ICC, IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~36kDa by Western blot.
Purity Detail:Immunoaffinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. 
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:EIF-2α, also known as eukaryotic translation initiation factor 2α, promotes the binding of the initiator tRNA to the 40S ribosomal subunits and controls translational rates via phosphorylation/dephosphorylation mechanisms. The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides an important control in the regulation of protein synthesis initiation through the phosphorylation of eIF-2α. Phosphorylated eIF-2α inhibits cell growth and induces apoptosis. Phosphorylation of eIF-2α occurs under a variety of conditions including viral infection, apoptosis, nutrient deprivation, heme-deprivation, and certain stresses. EIF-2 exists as a heterotrimeric protein composed of 3 nonidentical subunits, alpha (36 kDa), beta (38 kDa), and gamma (52 kDa).
IHC Analysis: Human pancreas tissue stained with eIF2α, pAb at 10µg/ml.
IHC Analysis: Human prostate tissue stained with eIF2 α, pAb at 10µg/ml.
IHC Analysis: Human vessel tissue stained with eIF2 α, pAb at 10µg/ml.
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KAP-CP130-Antibody-Blot ADI-KAP-CP130 IHC1 ADI-KAP-CP130 IHC2 ADI-KAP-CP130 IHC3

Product Literature References

Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress: S. ErLin, et al.; Mol. Biol. Cell 26, 1947 (2015), Application(s): Western Blotting, Abstract; Full Text
Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation: L. Brown, et al. ; Am. J. Physiol. Endocrinol. Metab. 297, E638 (2009), Application(s): WB using sheep tissue, Abstract;
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules: P. Anderson, et al. ; Mol. Biol. Cell 13, 195 (2002), Application(s): ICC, WB using human samples, Abstract;
PERK mediates cell-cycle exit during the mammalian unfolded protein response: J.A. Diehl, et al. ; PNAS 97, 12625 (2000), Application(s): WB using mouse samples, Abstract;

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