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p90/RSK1 polyclonal antibody

ADI-KAP-CC040-E 100 µg 475.00 USD
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Product Specification

Alternative Name:Ribosomal protein S6 kinase α1
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human p90 RSK1.
UniProt ID:Q15418
Species reactivity:Human, Mouse, Rat
Applications:ELISA, IP, WB
Recommended Dilutions/Conditions:ELISA (1µg/ml)
Immunoprecipitation (6µg/500-1500µg protein)
Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In TBS containing 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The p90 Ribosomal S6 kinases (RSKs) comprise a family of unique protein serine/threonine kinases that lie downstream of the mitogen activated protein kinases, predominantly ERK. Activation of ERK results in the phosphorylation and subsequent activation of RSKs. In turn, RSKs translocate to the nucleus where they phosphorylate a diverse range of nuclear substrates including c-Fos, estrogen receptor, NF-κB/IkappaBalpha, cAMP-response element-binding protein (CREB) and CREB-binding protein. RSKs play a critical role in mediating a number of biological responses including cell cycle regulation and protein synthesis.

Product Literature References

A high-throughput pipeline for validation of antibodies: K. Sikorski, et al.; Nat. Methods 15, 909 (2018), Abstract;

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